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第２日　５月１９日（木）　　ポスター会場（月光）

2P-23　　PDF

超百寿者血漿のN-結合型糖鎖におけるシアル酸結合様式の解析

(¹都健康長寿医セ研・ ²島津・ ³慶大)
^o津元裕樹¹・ 西風隆司²・ 三浦ゆり¹・ 阿部由紀子³・ 新井康通³・ 岩本慎一²・ 広瀬信義³・ 田中耕一²・ 遠藤玉夫¹

We developed a method for a linkage-specific sialic acid analysis of human plasma N-glycans by a combination of MALDI-TOF MS and sialic acid linkage-specific alkylamidation (SALSA). Using this method, over 100 N-glycans containing multi-branched and highly sialylated were observed in human plasma, and the ratios of α2,3-linked to α2,6-linked sialic acid in two-branched glycans containing fucose were increased in semisuper centenarians compared with those in aged controls.