1P-03 PDF
High-throughput therapeutic drug monitoring (TDM) with LC-MS/MS using either manual sample preparation or fully automated on-line SPE
Therapeutic drug monitoring (TDM) has proven a valuable tool for the patient-matched pharmacotherapy. The methods used for DM-analysis have to be reliable, fast and should offer multiplexing opportunities. RECIPE has developed two TDM Kit-Systems for LC-MS/MS that cover over 120 different drugs with just one analytical system. The MS9000 Kit-System offers manual sample preparation while the MS9050 Kit-System is working with fully automated sample preparation with no need for a liquid handling system. Both systems need only one analytical column and the same mobile phases for all drug-classes. For accurate and precise quantification these complete kits include serum multi-level calibrators (4 levels) and serum multi-level controls (2 levels) for quality assurance. Matrix effects are compensated using stable isotope labeled internal standards. For analysis of each drug-class separate Add-on sets are available. RECIPE's fully validated and CE IVD certified ClinMass® TDM Kit-Systems so far enable the fast, easy and reliable determination of 14 Tricyclic Antidepressants, 35 Benzodiazepines, 27 Antiepileptics and 26 Antidepressants in serum or plasma.