1A-W1-1740 PDF
LC/MS定量分析におけるマトリクス効果対策（序論）
Matrix effects have become a major concern in quantitative LC/MS analysis. The analyte(s) are interfered by co-elution with matrix compounds in the ionization process. Although the mechanisms involved in matrix effects have not been fully explored, some kinds of compounds are possible candidates to cause matrix effect. To minimize matrix effects, modification to the sample extraction methodology and improved chromatographic separation must be performed. In this workshop, we introduce about the approaches for the elimination of matrix effects in quantitative LC/MS analysis.