Program

Plenary Lectures

[Program]
■PL1
Mass spectrometry for nucleic acids biophysics
Valérie Gabelica (INSERM / Univ. Bordeaux)
Abstract (provisional)
■PL2
From Single Cell to Tissues and Then Life; History of its Analyses and the Task of Mass Spectrometry
Tsutomu Masujima (RIKEN QBiC)

Special Programs

[Program]
■Featured Lecture
Towards understanding of “unexpected” mass spectra: dissection based on ionization mechanisms
Speaker
Kenzo Hiraoka (Yamanashi Univ.)
Coordinator
Yayoi Hongo (RIKEN)
Outline
We are occasionally confused by obtaining "unexpected" mass spectra, even if we use commercial instruments and follow well established experimental protocols that are supposed to be appropriate for the analyses. In this session, we will select some case studies and dissect such "unexpected" mass spectra that are difficult to interpret based on manuals. Basic knowledge on physicochemical ionization mechanisms would help us solve many problems encountered in mass spec labs.
■Society Program 1
Founders of MSSJ
Speakers
Nobuo Takaoka (Kyusyu Univ.)
Yoshinao Wada (Osaka MCHRI)
Coordinator
Mitsuo Takayama (Yokohama City Univ.)
■Society Program 2
The work-life balance from the point of view of “iku-men” (MSSJ Gender Equality Workshop #2)
Speaker
Takayuki Kawashima (NPO KoDikara Nippon)
Coordinator
Shizuyo Horiyama (Mukogawa Women's Univ.)

Award Lecture

Day 2 Thursday, June 18[Program]

Oral Sessions

Day 1 Wednesday, June 17 [Program]
Day 2 Thursday, June 18 [Program]
Day 3 Friday, June 19 [Program]
Session Overview
■Title
Mass Spectrometry is making a big impact on biopharmaceuticals and health care
■Organizer
Naoyuki Yamada (Ajinomoto Co., Inc.)
■Co-organizer
Hideto Yamaguchi (Astellas Pharma Inc.)
■Keynote
Noritaka Hashii (National Institute of Health Sciences)
■Scope
Peptide and protein pharmaceuticals, such as recent therapeutic antibody and peptide vaccines, have been remarkably developed by genetic modification technologies. Mass spectrometry is also considered as one of key technologies in target discovery to drug development & manufacturing. In response to emergence of chemically modified protein pharmaceuticals such as PEGlyted proteins and antibody drug conjugates (ADC); mass spectrometry is now taking a new role on structure elucidation for those new modalities, e.g. conjugation number and site identification. Along with protein pharmaceuticals, oligonucleic acid pharmaceutical products are coming up to the development stage in accordance with progress in RNA & antisense research. Also, significant progress in iPS cell and ES cell research makes regenerative medicine and cell therapy as the most anticipated personalized medicine. However, there are still some high hurdles needed to overcome in practical usage of biologics, regenerative medicine and cell therapy due to their complexity. It is conceivable that mass spectrometry is a fairly important technology to solve those issues. How is mass spectrometry working in the life science field? Also, what are the expected issues that can be resolved by mass spectrometry? Those are to be discussed in this session and the corresponding presentations will be selected through a wide invitation.
■Keyword
Biologics, Mass spectrometry in medicare, Primary to high order structure analysis of protein and nuclear acid, Function analysis, Regenerative medicine
■Title
Advances in direct MS for biology, plant and food sciences, and clinical applications
■Organizer
Tohru Yamagaki (Suntory Foundation for Life Sciences)
■Co-organizer
Kanako Sekimoto (Yokohama City University)
■Keynote
Hiroshi Nonami (Ehime University)
■Scope
Direct MS techniques for biology such as newly developed ambient MS are bringing us a breakthrough for biological sciences, food and plant sciences, and clinical applications. Single-cell MS and imaging MS are widely applied to metabolites profiling and their imaging maps from cells to whole bodies. More developed direct MS and structure determination methods are required for the complex secondary metabolites as well as the primary metabolites. Here, we will discuss the recently developed techniques and applications in ambient ionization such as DART, DESI, etc., and MS such as single-cell MS, imaging MS, ambient MS, profiling MS of metabolites and organic small molecules from living things, including their structure determination methods with the fragmentation.
■Keyword
Metabolites, Ambient MS, Imaging MS, Plant, Clinical application
■Title
Mass Spectrometry and Toxin – Structure analysis, screening and detection
■Organizer
Tomoya Kinumi (AIST)
■Co-organizer
Shigeki Jin (Hokkaido University)
■Keynote
Yoichi Nakao (Waseda University)
■Scope
Toxin has been an important target for life science because of the wide variety of physiological function. Mass spectrometry plays a crucial role in this area, and the development of mass spectrometry is closely related to growing the field of organic chemistry of natural products. In this session, we will discuss the recent topics and review the overview of study about toxin, natural products and bioactive compound in terms of mass spectrometry.
■Keyword
Toxin, Natural product, Structure analysis, Bioactive compound, Pharmaceutical, Investigation
■Title
Introduction to software for automated identification of metabolites
■Organizer
Takaaki Nishioka (Nara Institute of Science and Technology)
■Scope
A bottleneck of metabolomics is the identification of metabolites that are detected by LC-MS. Ideally the metabolites are identified by referring their MS data observed to MS databases. However, a few of them has the MS reference data in databases; many of the detected remain unidentified. This is the major reason why the bottleneck is the identification. To solve the problem, public chemical substance databases such as PubChem and ChemSpider are recently considered as supplementary resources for the identification. Various informatics tools toward the automated identification have been developed these few years. In the present session, we will pick some to introduce their utilities and to discuss their strengths and weaknesses.
■Keyword
Metabolomics, Chemical annotation, Informatics
■Title
Application of Knudsen Cell Mass Spectrometry at High Temperature
■Organizer
Takashi Nagai (Chiba Institute of Technology)
■Scope
Knudsen cell mass spectrometry at high temperature is used in measurement of thermodynamic properties such as vapor pressure, activities, and so on. The volatilization properties and thermodynamic properties of materials at high temperature is necessary to research of the atomic energy-related field and smelting, plant design in the recycling and a process design. The various type of materials (solidus or molten metals, oxides, salts and its mixtures) used in these fields. Therefore the measurement of their properties has been done by various approaches. Since there is also various techniques in the measurement using a mass spectrometry, the researcher of these field exchanges information, and discusses recent results of research.
■Keyword
Thermodynamics, Phase diagram, Smelting・Recycling, Energy, Materials for nuclear power, Nuclear fuel, Molten salt
■Title
Novel Developments in Earth and Planetary Sciences Based on Mass Spectrometry
■Organizer
Teruyuki Maruoka (University of Tsukuba)
■Co-organizer
Ken-ichi Bajo (Hokkaido University)
■Keynote
Yoshihiro Furukawa (Tohoku University)
■Scope
Mass spectrometry has been one of the most essential techniques for Earth and Planetary Sciences. Although geoscientists in the 19th century discussed only major components in the target materials, they could discuss minor components and isotopic compositions after introducing mass spectrometry as a research tool. This meant not only the increase of analytical data but also the improvement of data quality. The techniques based on mass spectrometry, such as paleoenvironmental analysis of light stable isotopes, radiometric dating, and rare earth elements patterns, brought a revolution to Earth and Planetary Sciences. Besides the examples stated above, the introduction of novel mass spectrometry has produced novel developments for researchers. In this session, we would like to discuss the novel mass spectrometry techniques that will advance the research field in Earth and Planetary Sciences.
■Keyword
Isotope, Trace elements, Trace species, Molecular fossils (chemical fossils), Proxy, Chronology
■Title
Progress in MS hardware technologies
■Organizer
Toshiki Sugai (Toho University)
■Co-organizer
Nobuyuki Zen (AIST)
■Scope
Nowadays, various areas of analytical studies benefit from the mass spectrometry, where the progress in hardware instruments is mandatory. In this session, we call for the presentations of the recent developments in hardware technologies including ionization, mass separation, mobility, detector, and so on. Innovative technological proposals are also hotly welcomed as long as the contribution to the mass spectrometry is expected. We expect you to obtain fruitful knowledge about the state-of-the-art MS hardware technologies and the perspective of future MS instruments as well.
■Keyword
Ionizing method, Ion beam engineering, Mass separation, Mobility, Detector
■Title
Imaging mass spectrometry: Remarkable improvement and remaining issues
■Organizer
Takaya Satoh (JEOL)
■Co-organizer
Makiko Fujii (Kyoto University)
■Scope
The imaging mass spectrometry (IMS) has an advantage in organic analysis for ability to separate by molecular weight, where other spectroscopy methods can obtain only elemental information. In the last decade, IMS using MALDI-MS was improved in biological applications to assess the distribution of proteins, peptides, lipids, drugs and their metabolites in a tissue specimen. Secondary ion mass spectrometry (SIMS) is widely used for mapping and depth profiling of inorganic compounds. Recently, the applications to organic compounds are studied by developing novel ion source, such as metal cluster ions and argon cluster ions. But, the technical issues or possibilities of these techniques have been discussed separately. In this session, we would like to discuss future potential of the IMS for organic compounds using MALDI, SIMS and other novel techniques.
■Keyword
Imaging mass spectrometry, MALDI, SIMS
■Title
On-site mass spectrometry
■Organizer
Yuichiro Hashimoto (Hitachi, Ltd.)
■Co-organizer
Kanako Sekimoto (Yokohama City University)
■Keynote
Michisato Toyoda (Osaka University)
■Scope
Recently, needs for "on-site" mass spectrometry have been increasing in the fields of clinical, security, and environmental. Various techniques for on-site mass spectrometry are also being developed to meet the needs. In this symposium, we review current status of technologies such as ionization and mass spectrometer, and debate future prospects viewed from the needs side. It would offer a place to think about what’s needed for the future on-site mass spectrometry.
■Keyword
Onsite MS, Medical, Security, Environment
■Title
Fundamentals
■Organizer
Yasuhide Naito (GPI)
■Co-organizer
Kanako Sekimoto (Yokohama City University)
■Scope
Mass spectrometry involves multidisciplinary fields of basic sciences such as quantum physics, reaction dynamics, physical chemistry, electrochemistry, thermodynamics and electromagnetics. This session will focus on fundamental aspects of mass spectrometry, including processes of ionization, ion dissociation, Coulomb mutual interaction, ion-surface interaction and so on. Those who intend to thoroughly discuss the fundamental aspects from the standpoint of basic sciences are encouraged to present papers.
■Keyword
Exploiting basic sciences, Application to fundamental studies
■Title
Structural analysis of large biomolecules for revealing their function
■Organizer
Kazumi Saikusa (Hiroshima University)
■Co-organizer
Satoko Akashi (Yokohama City University)
■Keynote
Hugh I. Kim (POSTECH)
■Scope
Structural biology reveals important functions and mechanisms of biological macromolecules, such as proteins and nucleic acids, based on their structure. With the developments in instruments, mass spectrometry has been recognized as one of the established tools in structural biology. In the research and development of bio-pharmaceuticals, mass spectrometry also contributes to investigate the interaction and stability of proteins and protein complexes. In this session, we will discuss the present situation and the future prospects of mass spectrometry in structural biology.
■Keyword
Large biomolecule, Complex, Molecular interaction
■Title
Translational research and biomarker, Application of mass spectrometry on the present and the future
■Organizer
Noriko Ohashi (Mitsubishi Tanabe Pharma Corporation)
■Co-organizer
Kenichi Suzumura (Astellas Pharma Inc.)
■Keynote
Daisuke Saigusa (Tohoku University)
■Scope
It is necessary that medicines have excellent therapeutic efficacy and adequate safety profile. Furthermore, the discrimination for the necessity of therapy and the medical effectiveness in advance is extremely useful from the viewpoint of both patient and healthcare economics. In this view, Biomarker is helpful tool for the discovery research and development for the new drug, and is indispensable for diagnosis and treatment of various conditions and diseases. Translational research (TR) for drug discovery & development has become one of the most powerful solutions in transitioning New Chemical Entities from lab bench to bedside. Biomarkers in TR have been used to bridge the gap between the results of basic research for specific biomolecules and their incorporation into medical application. For this purpose, Mass spectrometry could provide highly valuable tools for biomarker research. In this session, we will review some applications of mass spectrometry- based quantitative analysis in biomarker discovery and drug development.
■Keyword
Biomarker, Translational research, Drug discovery, Clinical trials
■Title
Review of basic technologies for advances in metabolomics
■Organizer
Kazutaka Ikeda (RIKEN)
■Co-organizer
Yoshihiro Izumi (Osaka University)
■Keynote
Takeshi Bamba (Osaka University)
■Scope
Metabolomics was developed by Oliver S.G. and colleagues in 1998, and it has been widely applied to a wide variety of fields such as medicine, food, agriculture and environment with advancement of mass spectrometric techniques. The technical developments in sample preparation, analytical method, data analysis, etc. were recently toned down, and these technical applications are becoming mainstream in metabolome research. However, the conventional techniques are not sufficient to understand metabolic changes holistically, and further technical developments are required to overcome. In our session, we will reveal remaining technical challenges (quenching, completeness, quantification, reproducibility, sensitivity, identification, multi-omics analysis, etc.) and discuss new technology and application to solve them for the further advances in metabolomics.
■Keyword
Metabolomics, Technical challenge, Multi-omics analysis
■Title
On-site medical applications of mass spectrometric technology, and its contribution to social health care
■Organizer
Toyofumi Nakanishi (Osaka Medical College)
■Scope
The development of soft-ionization mass spectrometry enabled us to detect and identify high-molecular compounds, such as proteins and nucleotides controlled with biological processes, and so the achievements have been constantly contributed progresses of “Life Science” research. Although newly MS technologies had achieved rapidly advancing development for several years, but many problems that should be resolved still pile up in these MS fields. In this session, we would like to show you the valuable information by six novel forefront researchers engaged in various basic, applied and clinical studies including medicine, pharmacology and forensic toxicology with the soft ionization MS techniques. Moreover the resolution to these problems will bring a new breakthrough for the quantitative and qualitative analysis by the current MS technologies.
■Keyword
Soft-ionization technique, Application of life science, Contribution to social health, Quantitative analysis, Proposing of problems on MS analysis
■Title
Contributions of mass spectrometry to research and development of high-functional materials
■Organizer
Kanae Teramoto (JEOL)
■Co-organizer
Takahiro Hoshi (Nipponkayaku Co., Ltd.)
■Keynote
Takahiro Hoshi (Nipponkayaku Co., Ltd.)
■Scope
Analysis technology has played an important role in research and development of the high-functional materials which are based on advanced production technology. For characterization of these materials, their chemical and physical properties are analyzed with various analytical methods. In this symposium, roles and contributions of mass spectrometry are discussed with reviewing the progress in the development of high-functional materials and their analytical techniques.
■Keyword
High-functional material, Characterization, Separation, Ionization, Data processing

Poster Presentations

Day 1 Wednesday, June 17 [Program]
Day 2 Thursday, June 18 [Program]
Day 3 Friday, June 19 [Program]

Luncheon Seminar

Day 1 Wednesday, June 17 [Program]
Day 2 Thursday, June 18 [Program]
Day 3 Friday, June 19 [Program]

Timetable

Timetable(PDF
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