演題概要

オーラルセッション

第2日 5月15日(木) 10:20~10:40 A会場(オービットホール)

医薬品のイメージング質量分析における試料前処理法の標準化

(1国がん研2島根大医)
o新間秀一1大沢智子1津端由佳里2須谷顕尚2礒部威2濱田哲暢1

Methodological standardization in imaging mass spectrometry (IMS) is one of the active subjects in IMS studies. We visualize the drug distributions in a large number of tissues obtained from cancer patients. In order to visualize the drug delivery in each patient with high accuracy, we have to measure all specimens under the same conditions. In this viewpoint, the standardized procedure from sample preparations including high sensitive matrix application to image analysis is essential. In this presentation, we introduce the standardized procedure including two-step matrix application and discuss its effectiveness.