演題概要

オーラルセッション

第1日 5月14日(水) 14:20~15:00 A会場(オービットホール)

血液一滴の可能性を拓く -質量分析計と前処理技術を組み合わせた血清・血漿のプロテオミクス・ペプチドミクス解析-

(1北里大理2北里大理プロテオミクスセンター)
o小寺義男1,2

Serum and plasma contain thousands of different types of proteins and peptides, which can provide valuable information about the numerous processes that take place within the body. However, detailed analyses of proteins and peptides in serum and plasma are still challenging because of the presence of many high-abundance proteins, the large dynamic range of protein and peptide concentrations, rendering the extremely high complexity of the serum/plasma proteome. Therefore, we have to optimize both pretreatment strategies and analysis methods. Furthermore, verification and validation studies are necessary to clarify complicate biological process and to develop disease biomarkers from human serum/plasma because of considerable individual variability. In this symposium, I will talk about our challenges to develop biomarkers and find out maximum information about important biological processes from a drop of blood.